Task Two Biochemistry Dna /Rna

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Task 2 of Biochemistry Susan Ferreira Western Governor University GRT1- 208.5.2-01 .02 ,04-07 Task 2 of Biochemistry Task A. Molecular level of and RNA and DNA are nucleotides, a chemical structure used to make proteins, the building blocks of the living organisms designed to ensure successful reproduction. A prion is a protein that doesn't require a nucleotide to reproduce. When an abnormally folded prion protein runs into a normal prion protein, the normal protein transforms into another abnormally folded disease-causing prion. The result is a cascade of mutated protein. In cases of inherited prion disease, it's the gene mutation that causes abnormal folding of prion protein. Unfortunately, these are the same proteins used by brain cells in order to function properly, and so nerve cells die as a result, leading to a rapidly progressive dementia. BSE or bovine spongiform encephalopathy is a transmissible spongiform encephalopathy-TSE-that is transmitted via prions or infected protein. A prion is an abnormally folded protein. It is spread when cattle consume infected food such as animal protein or scrapie –infected sheep products. TSEs kill neurons in the brain causing the brain to appear spongelike. All know mammal prion diseases are caused by the prion protein known as PrP. The properly folded form is known as PRpC (meaning cellular). The misfolded form is known as PrPsc . The damage occurs when the PrPsc invades the PrPC. The disease progresses when a misfolded PrPSc molecule comes in contact with cellular form PrPC of this protein and converts them. The PrPsc is hydrophobic and wants to avoid the water inside the cell. The PrPsc protein passes on the misfolding onto the PrPC. The PrPsc is acting like a chaperone. Our normal chaperones cannot convert PrPsc back to PrPC, so the misfolding spreads. The PrPC

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