Mixed Connective Tissue Disease: Journal Article Analysis

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Journal Article Critique January 15, 2012 HCA/220 The article I chose is “Severe and refractory myositis in mixed connective tissue disease: a description of a rare case”. (MCTD) known as mixed connective tissue disease is a generalized connective tissue disorder represented by the existence of high titer (RNP) anti-U1 rib nucleoprotein antibodies combined with clinical 6eatures usually seen in lupus erythematous, polymyositis, and scleroderma. Mixed connective tissue disease (MCTD) usually takes several years before a confirm diagnosis is seen. Mixed connective tissue disease (MCTD) has overlapping features of Scl, SLE, and PM which appears over a period of time. The early stages of mixed connective tissue disease (MCTD) are…show more content…
| 2 | Myopathy | Myo | | pathy | Myopathy refers to any disease that affects muscle tissue. Diseases of the muscle result in weakness, inflammation, tetany (spasms), or paralysis | 3 | Scleroderma | Sclero | | derma | Scleroderma is a connective tissue disease that involves changes in the skin, blood vessels, muscles, and internal organs…show more content…
| 5 | Endomysium | my | Endo | um | Endomysium is the sheath of delicate reticular fibrils surrounding each muscle fiber | 6 | Electromyography | Myo | Electro | graphy | Electromyography is a test that checks the health of the muscles and the nerves that control the muscles. | 7 | Cytomegalovirus | Mega | Cyto | virus | Cytomegalovirus (CMV) is a double-stranded DNA virus and is a member of the Herpesviridae family | 8 | Ribonucleoprotein | Ribo | nucle | protein | Ribonucleoprotein is a nucleoprotein that contains RNA. | 9 | Toxoplasmosis | Toxo | plas | mosis | Toxoplasmosis is an infection due to the parasite Toxoplasma gondii. | 10 | Perivascular | Peri | vas | ar | Perivascular means near or around a vessel. | 1. African-Americans may have an increased risk of developing a polymyositis and poorer outcomes compared to Caucasians. 2. However most hereditary forms actually refer to inclusion body myopathy and not inclusion body myositis 3. Skin lesions called localized scleroderma are the most common in

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